BMS-779788
| CAS No. | 918348-67-1 | Cat. No. | BCP20751 |
| Name | BMS-779788 | ||
| Synonyms | BMS 779788; BMS779788; BMS-788; BMS 788; BMS788; XL-652; XL652; XL652; EXEL 04286652; EXEL04286652; EXEL-04286652; | ||
| Formula | C28H29ClN2O3S | M. Wt | 509.06 |
| Description | BMS-779788, also known as XL-652, EXEL 04286652 and BMS-788, is potent partial LXR agonist with LXRβ selectivity, which has an improved therapeutic window in the cynomolgus monkey compared with a full pan agonist. BMS-779788 induced LXR target genes in blood in vivo with an EC50 = 610 nM, a value similar to its in vitro blood gene induction potency. BMS-779788 was 29- and 12-fold less potent than the full agonist T0901317 in elevating plasma triglyceride and LDL cholesterol, respectively, with similar results for plasma cholesteryl ester transfer protein and apolipoprotein B. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | LXR | ||
Structure
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