GK921
| CAS No. | 1025015-40-0 | Cat. No. | BCP20748 |
| Name | GK921 | ||
| Synonyms | GK-921; GK 921; | ||
| Formula | C21H20N4O | M. Wt | 344.42 |
| Description | GK921 is a transglutaminase 2 (TGase 2) inhibitor. GK921 showed cytotoxicity to RCC (average GI50 in eight RCC cell lines: 0.905 μM). A single treatment with GK921 almost completely reduced tumor growth by stabilizing p53 in the ACHN and CAKI-1 preclinical xenograft tumor models. TGase 2 inhibitor GK921 abrogates RCC growth in xenograft tumor models, suggesting the possibility of a new therapeutic approach to RCC. | ||
| Pathways | Others Pathway | ||
| Targets | Others | ||
Structure
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