IMR-1

  • Chemical Properties
CAS No. 310456-65-6 Cat. No. BCP25522
Name IMR-1
Synonyms IMR 1; IMR1; Inhibitor of Mastermind Recruitment-1;
Formula C15H15NO5S2 M. Wt 353.41
  • Biological Activity
Description IMR-1 is a Mastermind Recruitment inhibitor. IMR-1 disrupted the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex on chromatin, thereby attenuating Notch target gene transcription. IMR-1 inhibited the growth of Notch-dependent cell lines and significantly abrogated the growth of patient-derived tumor xenografts.
Pathways Wnt/Stem Cell 
Targets Notch 

Structure

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