IMR-1
CAS No. | 310456-65-6 | Cat. No. | BCP25522 |
Name | IMR-1 | ||
Synonyms | IMR 1; IMR1; Inhibitor of Mastermind Recruitment-1; | ||
Formula | C15H15NO5S2 | M. Wt | 353.41 |
Description | IMR-1 is a Mastermind Recruitment inhibitor. IMR-1 disrupted the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex on chromatin, thereby attenuating Notch target gene transcription. IMR-1 inhibited the growth of Notch-dependent cell lines and significantly abrogated the growth of patient-derived tumor xenografts. | ||
Pathways | Wnt/Stem Cell | ||
Targets | Notch |
Structure
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