ML364
| CAS No. | 1991986-30-1 | Cat. No. | BCP20769 |
| Name | ML364 | ||
| Synonyms | ML-364;ML 364; | ||
| Formula | C24H18F3N3O3S2 | M. Wt | 517.54 |
| Description | ML364 is a small molecule inhibitor of the deubiquitinase USP2 with potential anticancer activity. ML364 has an IC50 of 1.1 μm in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate. Direct binding of ML364 to USP2 was demonstrated using microscale thermophoresis. ML364 induced an increase in cellular cyclin D1 degradation and caused cell cycle arrest as shown in Western blottings and flow cytometry assays utilizing both Mino and HCT116 cancer cell lines. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DUB | ||
Structure
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