RN-1
| CAS No. | 1781835-13-9 | Cat. No. | BCP20812 |
| Name | RN-1 | ||
| Synonyms | RN-1 Dihydrochloride; | ||
| Formula | C23H29N3O2 | M. Wt | 452.42 |
| Description | Lysine-specific demethylase 1 (LSD1) belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases that include monoamine oxidases (MAOs). RN-1 is a potent, irreversible inhibitor of LSD1 (IC50 = 70 nM).2 It is much less effective against MAO-A and MAO-B (IC50s = 0.51 and 2.8 μM, respectively).2 Following intraperitoneal administration, RN-1 penetrates the blood-brain barrier and distributes in mice to a brain/plasma exposure ratio of 88.9. It blocks long-term but not short-term memory in mice.2 RN-1 also induces cytotoxicity in ovarian cancer cell lines and induces fetal hemoglobin synthesis while reducing disease pathology in sickle cell mice. | ||
| Pathways | Epigenetics | ||
| Targets | Histone Demethylase | ||
Structure
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