MI-136
| CAS No. | 1628316-74-4 | Cat. No. | BCP20862 |
| Name | MI-136 | ||
| Synonyms | MI 136; MI136; | ||
| Formula | C23H21F3N6S | M. Wt | 470.52 |
| Description | MI-136 is an inhibitor of the menin-MLL interaction (IC50 = 31 nM; Kd = 23.6 nM).1,2 By blocking MLL recruitment predominantly at the level of the menin-MLL interaction, it can inhibit androgen receptor (AR)-mediated transcription. At 40 mg/kg, MI-136 has been shown to block AR signaling, inhibiting the growth of castration-resistant tumors in mice. | ||
| Pathways | Hormone Pathay | ||
| Targets | Androgen Receptor | ||
Structure
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