PD-1-IN-1
| CAS号 | 1673534-76-3 | 货号 | BCP25947 |
| 中文名 | PD-1-IN-1 | ||
| 英文名 | PD-1-IN-1 | ||
| 中文别名 | |||
| 英文别名 | |||
| 分子式 | C12H20N6O7 | 分子量 | 360.32 |
| 生物活性 | PD-1-IN-1 is an inhibitor of programmed cell dealth-1 (PD-1) extracted from patent WO 2015033299 A1, compound example 4. CA-170 is an orally bioavailable small molecule inhibitor of the immune checkpoint regulatory proteins programmed cell death ligand-1 (PD-L1; B7-H1; CD274), PD-L2, and V-domain immunoglobulin (Ig) suppressor of T-cell activation (VISTA; programmed death 1 homolog; PD1H; PD-1H), with potential negative immune checkpoint regulatory and antineoplastic activities. CA-170 targets and binds to PD-L1, PD-L2 and VISTA. This inhibits PD-L1/PD-L2/VISTA-mediated signaling, abrogates the PD-L1-, PD-L2- and VISTA-induced suppression of T-lymphocyte immune responses, enhances cytotoxic T-cell proliferation and activation against tumor cells, increases cytokine production by T-cells, and inhibits tumor cell growth. PD-L1, PD-L2 and VISTA, negative checkpoint molecules of immune activation, play key roles in the suppression of T-cell functions. | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | PD 1/PD L1 | ||
结构式
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