OG-L002 hydrochloride
| CAS号 | 1357298-75-9 | 货号 | BCP25948 |
| 中文名 | OG-L002 hydrochloride | ||
| 英文名 | OG-L002 hydrochloride | ||
| 中文别名 | |||
| 英文别名 | OG-L002 HCl; OG L002 HCl; OGL002 HCl; OG L002 Hydrochloride; OGL002 Hydrochloride; | ||
| 分子式 | C15H16ClNO | 分子量 | 261.75 |
| 生物活性 | OG-L002 HCl is a highly specific inhibitor of lysine specific demethylase 1 (LSD1, also known as KDM1A, or H3K9 demethylase) (IC50, ~0.02 µM). OG-L002 potently repressed herpes simplex virus (HSV) IE gene expression, genome replication, and reactivation from latency. It suppressed primary lytic infection of HSV in vivo in a mouse model. This highlights the potential for drugs that inhibit a virus’ ability to modify chromatin for treating or even preventing viral diseases like herpes, chicken pox, and shingles. | ||
| 信号通路 | Epigenetics | ||
| 靶 点 | Histone Demethylase | ||
结构式
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