Pocapavir
| CAS No. | 146949-21-5 | Cat. No. | BCP20876 |
| Name | Pocapavir | ||
| Synonyms | SCH-48973; SCH48973; SCH 48973; V074; V 073; V-073; | ||
| Formula | C21H17Cl3O3 | M. Wt | 423.71 |
| Description | Pocapavir, also known as SCH-48973 and V-073, is a potent, selective, antienterovirus agent. SCH-48973 had antiviral activity (50% inhibitory concentrations [IC50s]) of 0.02 to 0.11 microg/ml, with no detectable cytotoxicity at 50 microg/ml. SCH-48973 inhibited 80% of 154 recent human enterovirus isolates at an IC50 of 0.9 microg/ml. The affinity constant (Ki) for SCH-48973 binding to poliovirus was 8.85 x 10(-8) M. SCH-48973 demonstrated efficacy in a murine poliovirus model of enterovirus disease. SCH-48973 represents a potential candidate for therapeutic intervention against enterovirus infections. | ||
| Pathways | Microbiology/Virology | ||
| Targets | Enterovirus | ||
Structure
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