SAG Hydrochloride
  • Chemical Properties
CAS No. 2095432-58-7 Cat. No. BCP26130
Name SAG Hydrochloride
Synonyms SAG HCl;
Formula C28H28ClN3OS.HCl M. Wt 526.52
  • Biological Activity
Description SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); sag antagonizes cyclopamine action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM). SAG induces pathway activation independently of Ptch proteins. The Smoothened receptor (SMO) mediates signal transduction in the hedgehog pathway, which is implicated in normal development and carcinogenesis. SMO antagonists can suppress the growth of some tumours.
Pathways GPCR/G Protein 
Targets Smoothened/Smo 

Structure

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