XL647(Racemate)

CAS No.	874286-84-7	Cat. No.	BCP02839
Name	XL647(Racemate)
Synonyms	XL 647;XL-647; EXEL7647; EXEL-7647; EXEL7647; KD-019; KD019; KD 019;Tesevatinib;
Formula	C24H25Cl2FN4O2	M. Wt	491.39

Description	XL647 binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including epidermal growth factor receptor, epidermal growth factor receptor 2, vascular endothelial growth factor receptor, and ephrin B4 .Tesevatinib, also known as XL647, EXEL-7647 and KD-019, is a n orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. XL647 binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor receptor 2 (HER2; ERBB2), vascular endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4). This may result in the inhibition of tumor growth and angiogenesis, and tumor regression.
Pathways	Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway
Targets	Ephrin Receptor VEGFR EGFR

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