GSK 269962 trihydrochloride
| CAS号 | 925213-80-5 | 货号 | BCP26170 |
| 中文名 | GSK 269962 trihydrochloride | ||
| 英文名 | GSK 269962 trihydrochloride | ||
| 中文别名 | |||
| 英文别名 | GSK269962 3HCl; GSK269962 trihydrochloride; GSK269962; GSK 269962; GSK-269962; GSK269962A; GSK 269962A; GSK-269962A; GSK26996B; | ||
| 分子式 | C29H33Cl3N8O5 | 分子量 | 679.98 |
| 生物活性 | GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK-I and ROCK-II, respectively. GSK 269962 could reverse corticosterone-induced depressive-like behaviour and changes in cystometric parameters associated with detrusor overactivity, as well as undo the alterations of several biomarkers related to both disorders (i.e., pro-inflammatory/anti-inflammatory cytokines and neurotrophins) in serum, urinary bladder, and different brain structures. | ||
| 信号通路 | Cell Cycle/DNA Damage TGF beta/Smad Wnt/Stem Cell | ||
| 靶 点 | ROCK | ||
结构式
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