ALW-II-41-27

CAS No.	1186206-79-0	Cat. No.	BCP26205
Name	ALW-II-41-27
Synonyms	ALW II-41-27; ALWII-41-27; ALW-II-4127; ALW II-4127; ALWII-4127;
Formula	C32H32F3N5O2S	M. Wt	607.69

Description	ALW-II-41-27 is a Eph receptor tyrosine kinase inhibitor. pharmacologic inhibition of EPHA2 by the small-molecule inhibitor ALW-II-41-27 decreased both survival and proliferation of erlotinib-resistant tumor cells and inhibited tumor growth in vivo. ALW-II-41-27 was also effective in decreasing viability of cells with acquired resistance to the third-generation EGFR TKI AZD9291. Collectively, these data define a role for EPHA2 in the maintenance of cell survival of TKI-resistant, EGFR-mutant lung cancer and indicate that EPHA2 may serve as a useful therapeutic target in TKI-resistant tumors.
Pathways	Angiogenesis/Protein Tyrosine Kinase
Targets	Ephrin Receptor

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