NKP-1339
| CAS号 | 197723-00-5 | 货号 | BCP26252 |
| 中文名 | NKP-1339 | ||
| 英文名 | NKP-1339 | ||
| 中文别名 | |||
| 英文别名 | NKP 1339;NKP1339;KP1339;KP 1339;KP-1339; | ||
| 分子式 | C14H12Cl4N4NaRu | 分子量 | 502.14 |
| 生物活性 | NKP-1339, also known as KP-1339, is a ruthenium-containing cancer agent targeting transferrin with potential antineoplastic activity. Upon intravenous administration, NKP-1339 (Ru3+) binds to transferrin (Tf) and is taken up via Tf receptors (TfR), which are overexpressed on cancer cells. Once inside the cell, NKP-1339 is released from Tf and is reduced, within the acidic environment of the endosomes, to its active form NKP-119 (Ru2+). In turn, the active form induces a redox reaction, thereby leading to the formation of reactive oxygen species (ROS) which inhibits GRP78 and SOD, endoplasmic reticulum-stress modulating molecules as well as BAG4 and ERK, program cell death regulating molecules.This eventually induces caspase-dependent apoptosis. | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | Others | ||
结构式
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