维多珠单抗
| CAS号 | 943609-66-3 | 货号 | BCP26256 |
| 中文名 | 维多珠单抗 | ||
| 英文名 | Vedolizumab | ||
| 中文别名 | |||
| 英文别名 | MLN-02; LDP-02; MLN0002;Anti-Human lymphocyte α4β7 integrin, Humanized Antibody; | ||
| 分子式 | C6528H10072N1732O2042S42 | 分子量 | 146834.53 |
| 生物活性 | Vedolizumab is a monoclonal antibody binds to integrin α4β7. Vedolizumab blocks the α4β7 integrin, results in gut-selective anti-inflammatory activity. Vedolizumab binds to memory CD4(+) T and B lymphocytes with subnanomolar potency (EC(50) = 0.3-0.4 nM). Vedolizumab also binds to eosinophils at high levels, and to naive T-helper lymphocytes, naive and memory cytotoxic T lymphocytes, B lymphocytes, natural killer cells, and basophils at lower levels. Vedolizumab selectively inhibits adhesion of alpha(4)beta(7)-expressing cells to mucosal addressin cell adhesion molecule 1 (median inhibition concentration [IC(50)] = 0.02-0.06 microg/ml) and fibronectin (IC(50) = 0.02 microg/ml), but not vascular cell adhesion molecule. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | Integrin | ||
结构式
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