BMS-852927
| CAS No. | 1256918-39-4 | Cat. No. | BCP23542 |
| Name | BMS-852927 | ||
| Synonyms | BMS 852927; BMS852927; XL041; XL-041; XL 041; | ||
| Formula | C29H28Cl2F2N2O4S | M. Wt | 609.51 |
| Description | BMS-852927, also known as XL041, is a LXR partial agonist. BMS-852927 shows LXRbeta/LXRalpha: 88%/20% activity; hWBA ABCA1 EC50 = 9 nM (26%); hWBA ABCG1 EC50 = 10 nM (33%); Binding alpha1-AGP = 97.3%. BMS-852927 induces ABCA1 and ABCG1 RCT targets in human whole blood at nanomolar drug exposures with robust LXRβ agonism and limited LXRα agonist activity. BMS-852927 is LXRβ-selective compound, had favorable profiles in animal models with a wide therapeutic index in cynomolgus monkeys and mice. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | LXR | ||
Structure
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