AZD-5991 Racemate
| CAS号 | 2143010-83-5 | 货号 | BCP23513 |
| 中文名 | AZD-5991 Racemate | ||
| 英文名 | AZD-5991 Racemate | ||
| 中文别名 | CAS:2143061-81-6;2143061-82-7; | ||
| 英文别名 | AZD5991; AZD-5991; AZD 5991;CAS:2143061-81-6;2143061-82-7; | ||
| 分子式 | C35H34ClN5O3S2 | 分子量 | 672.26 |
| 生物活性 | AZD5991 is a potent and selective Mcl-1 inhibitor for treatment of hematologic cancers. AZD5991 is a rationally designed macrocycle with sub-nanomolar affinity for Mcl-1. AZD5991 is an inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, AZD5991 binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins, and promoting apoptosis of cells overexpressing Mcl-1. | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | Bcl2 | ||
结构式
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