Cintirorgon
| CAS号 | 2055536-64-4 | 货号 | BCP28882 |
| 中文名 | Cintirorgon | ||
| 英文名 | Cintirorgon | ||
| 中文别名 | |||
| 英文别名 | LYC 55716;LYC55716; LYC-55716; | ||
| 分子式 | C27H23F6NO6S | 分子量 | 603.53 |
| 生物活性 | Cintirorgon, also known as LYC-55716, is a potent and orally active RORgamma agonist with potential immunomodulatory and antineoplastic activities. LYC-55716 selectively binds to the nuclear receptor transcription factor RORg, forming a receptor complex that translocates to the nucleus, and binds to ROR response elements (ROREs), enhancing the function, proliferation and survival of type 17 T cells, including Th17 (helper T cells) and Tc17 (cytotoxic T cells). | ||
| 上下游产品 | 2055538-47-9（Cintirorgon sodium） | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | ROR | ||
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RORγt agonist enhances anti-PD-1 therapy by promoting monocyte-derived dendritic cells through CXCL10 in cancers
购于瀚香生物(Biochempartner)的Cintirorgon(CAS:2055536-64-4)被引用 |
结构式
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