TAK-659 2HCl
| CAS No. | 1312691-41-0 | Cat. No. | BCP28885 |
| Name | TAK-659 2HCl | ||
| Synonyms | TAK659 dihydrochloride;TAK 659 dihydrochloride;TAK-659 dihydrochloride;TAK659 2HCl ;TAK 659 2HCl ; | ||
| Formula | C17H23Cl2FN6O | M. Wt | 417.31 |
| Description | TAK-659 is a potent spleen tyrosine kinase (syk) inhibitor under the development of Takeda Oncology, with potential anti-inflammatory, immunomodulating, and antineoplastic activities. TAK-659 may inhibit the activity of syk, which abrogates downstream BCR (B-cell receptor) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Phase I/II for the treatment Acute myeloid leukaemia, phase I for the treatment of Breast cancer, Gastrointestinal cancer, Head and neck cancer, Lymphoma, Non-small cell lung cancer and Solid tumours was on-going. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Syk | ||
Structure
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