OTS514 S-isomer HCl
| CAS号 | 1338545-92-8 | 货号 | BCP28890 |
| 中文名 | OTS514 S-isomer HCl | ||
| 英文名 | OTS514 S-isomer HCl | ||
| 中文别名 | |||
| 英文别名 | OTS 514 S-isomer HCl; OTS-514 S-isomer HCl; | ||
| 分子式 | C21H21ClN2O2S | 分子量 | 400.92 |
| 生物活性 | OTS514 is a potent TOPK (T-LAK cell-originated protein kinase) inhibitor. OTS514 exhibits growth suppressive effect on small cell lung cancer. TS514 effectively suppressed growth of SCLC cell lines (IC50 ; 0.4 ~ 42.6 nM) and led to their apoptotic cell death. Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity, which was involved in stemness of CSC. Furthermore, OTS514 treatment reduced CD90-positive SCLC cells and showed higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells. | ||
| 信号通路 | MAPK Pathway | ||
| 靶 点 | TOPK | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！