OTS514 hydrochloride
| CAS No. | OTS514HCl | Cat. No. | BCP28892 |
| Name | OTS514 hydrochloride | ||
| Synonyms | OTS 514 hydrochloride;OTS-514 hydrochloride;OTS514 HCl;OTS-514 HCl;OTS 514 HCl; | ||
| Formula | C21H21ClN2O2S | M. Wt | 400.92 |
| Description | OTS514 is a highly potent and selective TOPK inhibitor with IC50 of 2.6 nM; shows selectivity against a panel of 60 kinases (at 0.2 uM, 11.5-18.5% inhibition); strongly suppresses the growth of TOPK-positive cancer cells; demonstrates in vivo efficacy but causes severe hematopoietic toxicity. | ||
| Pathways | MAPK Pathway | ||
| Targets | TOPK | ||
Structure
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