Pradefovir
| CAS No. | 625095-60-5 | Cat. No. | BCP28900 |
| Name | Pradefovir | ||
| Synonyms | Remofovir; ICN-2001-3; MB-06866; MB-6866; ICN-20013; ICN2001-3; MB06866; MB6866; ICN20013; | ||
| Formula | C17H19ClN5O4P | M. Wt | 423.79 |
| Description | Pradefovir, also known as Remofovir, ICN-2001-3; MB-06866; MB-6866; ICN-20013, is a reverse transcriptase inhibitor potentially for treatment of chronic HBV infection. Pradefovir is also a liver-targeted prodrug of adefovir. After metabolic activation, Pradefovir was converted to PMEA (9-(2-phosphonylmethoxyethyl)adenine ) in human liver microsomes with a K(m) of 60 microM, a maximum rate of metabolism of 228 pmol/min/mg protein, and an intrinsic clearance of about 359 ml/min. | ||
| Pathways | Microbiology/Virology | ||
| Targets | Reverse Transcriptase | ||
Structure
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