YHO-13351 (free base)
| CAS No. | 912288-64-3 | Cat. No. | BCP28919 |
| Name | YHO-13351 (free base) | ||
| Synonyms | YHO13351 (free base)；YHO 13351 (free base); | ||
| Formula | C26H33N3O4S | M. Wt | 483.63 |
| Description | YHO-13351 is an orally available prodrug of YHO-13177, which can specifically reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo; YHO-13351 is rapidly converted into YHO-13177 after its oral or intravenous administration, significantly increases the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppressed the tumor growth in an HCT116/BCRP xenograft model coadministration of irinotecan. | ||
| Pathways | Ion Channel/Membrane Transporter | ||
| Targets | BCRP | ||
Structure
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