PF-06260933
| CAS No. | 1811510-56-1 | Cat. No. | BCP28968 |
| Name | PF-06260933 | ||
| Synonyms | PF06260933; PF 06260933; | ||
| Formula | C16H13ClN4 | M. Wt | 296.76 |
| Description | PF-06260933 is potent and selective MAP4K4 inhibitor (IC50 value 3.7 nM for MAP4K4 a.k.a. HGK or ZC1) with suitable PK properties in mouse to be used as a tool in an in vivo model of diabetes, vascular inflammation and atherosclerosis. Robustly prevented TNF-α-mediated endothelial permeability in vitro, similar to MAP4K4 knockdown, and without alteration of plasma lipid content. | ||
| Pathways | MAPK Pathway | ||
| Targets | MAP4K | ||
Structure
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