T56-LIMKi

CAS No.	924473-59-6	Cat. No.	BCP28984
Name	T56-LIMKi
Synonyms	T56 LIMKi; T56LIMKi; T5601640; T56-LIM Kinase Inhibitor;
Formula	C19H14F3N3O3	M. Wt	389.33

Description	T5601640, also known as T56-LIMKi, has high specific inhibitory activity for LIMK2 and shows little or no activity with LIMK1. T5601640 is an inhibitor of LIM kinase 2 (LIMK2) that inhibits LIMK2-mediated cofilin phosphorylation. It reduces the levels of phosphorylated cofilin (p-cofilin) in mouse embryonic fibroblasts (MEF) lacking neurofibromin (Nf1-/-; IC50 = 30 µM), which normally have high levels of p-cofilin. T5601640 (50 µM) decreases actin stress fiber formation, inhibits cell migration, and inhibits colony formation of Nf1-/- MEF cells. It inhibits proliferation of ST88-14, U87, and PANC-1 cells with IC50 values of 18.3, 7.4, and 35.2 µM, respectively, and also decreases p-cofilin levels by 20, 24, and 46%, respectively. Oral gavage administration of T5601640 (60 mg/kg) decreases tumor volume and cofilin phosphorylation in a PANC-1 nude mouse xenograft model.
Pathways	Cell Cycle/DNA Damage
Targets	LIMK

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