AZD1390
| CAS No. | 2089288-03-7 | Cat. No. | BCP28994 |
| Name | AZD1390 | ||
| Synonyms | AZD-1390; AZD 1390; | ||
| Formula | C27H32FN5O2 | M. Wt | 477.58 |
| Description | AZD1390 is a potent and selective ATM inhibitor with the ability to cross the blood-brain barrier suitable for the treatment of intracranial malignancies.AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50 = 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases. AZD1390 displays excellent oral bioavailability in preclinical species (66% in rat and 74% in dog), is not a substrate for human efflux transporters, and has been shown to efficiently cross the BBB in non-human primate PET studies. | ||
| Pathways | Cell Cycle/DNA Damage PI3K/Akt/mTOR | ||
| Targets | ATM/ATR | ||
Structure
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