SR-0987
| CAS No. | 303126-97-8 | Cat. No. | BCP29012 |
| Name | SR-0987 | ||
| Synonyms | SR0987; SR 0987; | ||
| Formula | C16H10ClF6NO2 | M. Wt | 397.7 |
| Description | SR 0987 is an agonist of the T cell-specific isoform of RORγ, inducing reporter gene expression with an EC50 value of ~800 nM. Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA and ionomycin, increases expression of the RORγt target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged. Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | ROR | ||
Structure
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