SR-0987
| CAS号 | 303126-97-8 | 货号 | BCP29012 |
| 中文名 | SR-0987 | ||
| 英文名 | SR-0987 | ||
| 中文别名 | |||
| 英文别名 | SR0987; SR 0987; | ||
| 分子式 | C16H10ClF6NO2 | 分子量 | 397.7 |
| 生物活性 | SR 0987 is an agonist of the T cell-specific isoform of RORγ, inducing reporter gene expression with an EC50 value of ~800 nM. Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA and ionomycin, increases expression of the RORγt target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged. Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | ROR | ||
结构式
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