WNK463
| CAS No. | 2012607-27-9 | Cat. No. | BCP29014 |
| Name | WNK463 | ||
| Synonyms | NVP-WNK463; NVP-WNK 463; NVP-WNK-463;WNK-463; WNK 463; | ||
| Formula | C21H24F3N7O2 | M. Wt | 463.46 |
| Description | WNK463, also known as NVP-WNK463, is a potent and orally bioavailable pan-WNK-kinase inhibitor. WNK463 affects blood pressure and body fluid and electro-lyte homeostasis, consistent with WNK-kinase-associated physiology and pathophysiology. The With-No-Lysine (K) (WNK) kinases play a critical role in blood pressure regulation and body fluid and electrolyte homeostasis.In vivo: WNK463, that exploits unique structural features of the WNK kinases for both affinity and kinase selectivity. In rodent models of hypertension, WNK463 affects blood pressure and body fluid and electro-lyte homeostasis, consistent with WNK-kinase-associated physiology and pathophysiology. | ||
| Pathways | Others Pathway | ||
| Targets | Others | ||
Structure
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