Ziconotide
CAS No. | 107452-89-1 | Cat. No. | BCP29050 |
Name | Ziconotide | ||
Synonyms | SNX-111;omega-Conopeptide MVIIA (Conus);H-Cys(1)-Lys-Gly-Lys-Gly-Ala-Lys-Cys(2)-Ser-Arg-Leu-Met-Tyr-Asp-Cys(3)-Cys(1)-Thr-Gly-Ser-Cys(2)-Arg-Ser-Gly-Lys-Cys(3)-NH2; | ||
Formula | C102H172N36O32S7 | M. Wt | 2639.13 |
Description | Ziconotide is a synthetic, nonopiod, twenty-five amino acid polybasic peptide analogue of an omega-conotoxin derived from the marine snail Conus magus with analgesic activity. Ziconotide appears to block neuronal N-type voltage-sensitive calcium channels (NCCB), inhibiting transmission from pain-sensing primary nociceptors. This agent may exhibit significant analgesic activity in refractory pain. | ||
Pathways | Ion Channel/Membrane Transporter | ||
Targets | Calcium Channel |
Structure
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