MK-3903
| CAS No. | 1219737-12-8 | Cat. No. | BCP29075 |
| Name | MK-3903 | ||
| Synonyms | MK 3903; MK3903; | ||
| Formula | C27H19ClN2O3 | M. Wt | 454.91 |
| Description | MK-3903 is a potent and selective AMPK activator (EC50 = 8 nM). MK-3903 exhibited robust target engagement in mouse liver following oral dosing, leading to improved lipid metabolism and insulin sensitization in mice. Chronic oral administration of MK-3903 robustly increased ACC phosphorylation in liver with more modest effects in skeletal muscle. Treatment of various mouse models with MK-3903 resulted in expected alterations in lipid metabolism and improvements in a measure of insulin sensitization. | ||
| Pathways | PI3K/Akt/mTOR Epigenetics | ||
| Targets | AMPK | ||
Structure
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