MAK-683

CAS No.	1951408-58-4	Cat. No.	BCP29116
Name	MAK-683
Synonyms	EED inhibitor-1;CPD 1111; MAK 683; MAK683;CPD1111;CPD-1111;
Formula	C20H17FN6O	M. Wt	376.39

Description	MAK-683 is a potent inhibitor of embryonic ectoderm development protein (EED) and allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity. Upon administration, MAK683 selectively binds to the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), which leads to a conformational change in the EED H3K27me3-binding pocket and prevents the interaction of EED with the histone methyltransferase enhancer zeste homolog 2 (EZH2).
Pathways	Epigenetics
Targets	Epigenetic Reader Domain

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