CU-CPT-9b
CAS No. | 2165340-32-7 | Cat. No. | BCP29122 |
Name | CU-CPT-9b | ||
Synonyms | CU-CPT-9B; CPD2004;CU-CPT9b; | ||
Formula | C17H15NO2 | M. Wt | 265.31 |
Description | CU-CPT-9B is a potent, selective TLR8 inhibitor with IC50 of 0.7 nM, Kd of 21 nM, and negligible cytotoxicity; shows no significant inhibition for other TLRs at 1 uM in cellular assays; consistently recognizes an allosteric pocket on the protein-protein interface, stabilizing the inactive TLR8 dimer. | ||
Pathways | Others Pathway | ||
Targets | TLR |
Structure
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