UM164
| CAS号 | 903564-48-7 | 货号 | BCP29207 |
| 中文名 | UM164 | ||
| 英文名 | UM164 | ||
| 中文别名 | |||
| 英文别名 | UM 164;UM-164; | ||
| 分子式 | C30H31F3N8O3S | 分子量 | 640.69 |
| 生物活性 | UM164 is a movel potent, dual c-Src/p38 with Kd of 2.7 nM (c-Src), potently inhibits both p38α and p38β; inhibits c-Src autophosphorylation in TNBC cell lines, and shows potent antiproliferative activity with mean GI50 of 160 nM, alters the cell localization of c-Src in TNBC cells; completely inhibits p38 MAPK phosphorylation in SUM 149 cells at 50 nM; demonstrates potent anti-TNBC activity in xenograft models with limited in vivo toxicity. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase MAPK Pathway | ||
| 靶 点 | Src/Bcr Abl p38 MAPK | ||
结构式
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