KIN-1148
| CAS No. | 1428729-56-9 | Cat. No. | BCP29251 |
| Name | KIN-1148 | ||
| Synonyms | KIN 1148; KIN1148; | ||
| Formula | C19H11N3OS2 | M. Wt | 361.44 |
| Description | KIN-1148 is a IRF3 agonist. IN1148 induced dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. Prime-boost immunization of mice with a suboptimal dose of a monovalent pandemic influenza split virus H1N1 A/California/07/2009 vaccine plus KIN1148 protected against a lethal challenge with mouse-adapted influenza virus (A/California/04/2009) and induced an influenza virus-specific IL-10 and Th2 response by T cells derived from lung and lung-draining lymph nodes. | ||
| Pathways | Microbiology/Virology Others Pathway | ||
| Targets | Influenza Virus Others | ||
Structure
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