艾培替尼
| CAS号 | 908305-13-5 | 货号 | BCP29362 |
| 中文名 | 艾培替尼 | ||
| 英文名 | Epertinib | ||
| 中文别名 | |||
| 英文别名 | S-222611; S222611; S 222611; | ||
| 分子式 | C30H27ClFN5O3 | 分子量 | 560.02 |
| 生物活性 | Epertinib, also known as S-222611, is an oral reversible dual tyrosine kinase inhibitor of EGFR and HER2, currently under trials in patients with solid tumours. S-222611 selectively inhibited kinases with IC50 s below 10 nmol/L. S-222611 also inhibited intracellular kinase activity and the growth of EGFR-expressing and HER2-expressing cancer cells. In addition, S-222611 showed potent antitumor activity over lapatinib in a variety of xenograft models. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| 靶 点 | EGFR HER2 | ||
结构式
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