Sardomozide dihydrochloride

CAS No.	138794-73-7	Cat. No.	BCP29424
Name	Sardomozide dihydrochloride
Synonyms	CGP 48664A;CGP-48664A;CGP48664A;
Formula	C11H16Cl2N6	M. Wt	303.19

Description	Sardomozide dihydrochloride, also known as CGP48664A, is a second-generation polyamine synthesis inhibitor, which inhibits the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). SAM486 is more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG). Preclinical testing confirmed promising antiproliferative activity. The in vitro tests showed that p53 wild-type NB cells were highly sensitive to SAM486A treatment. Most notably, SAM486A treatment resulted in the rapid accumulation of proapoptotic proteins p53 and Mdm2.
Pathways	Others Pathway
Targets	Others

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