GSK-F1
| CAS号 | 1402345-92-9 | 货号 | BCP29575 |
| 中文名 | GSK-F1 | ||
| 英文名 | GSK-F1 | ||
| 中文别名 | |||
| 英文别名 | 1384097-27-1；rac-GSK-F1; | ||
| 分子式 | C27H18F5N5O4S | 分子量 | 603.52 |
| 生物活性 | GSK-F1 is a potent inhibitor of PI4KA. It has markedly better pharmacokinetic properties in vivo with respects to GSK-A1 . GSK-F1 does not cross the blood-brain barrier. Phosphatidylinositol 4-kinase type IIIα (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. RNAi studies have shown that PI4KA is a mandatory host factor in HCV replication. Down-regulation of PI4KA appears to be reasonably tolerated by cultured cell models and results. | ||
| 信号通路 | PI3K/Akt/mTOR | ||
| 靶 点 | PI4K | ||
结构式
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