LY2828360
| CAS No. | 1231220-79-3 | Cat. No. | BCP29625 |
| Name | LY2828360 | ||
| Synonyms | LY 2828360; LY-2828360; | ||
| Formula | C22H27ClN6O | M. Wt | 426.95 |
| Description | LY2828360 is a novel potent, selective, and efficacious G protein-biased CB2 agonist that attenuates chemotherapy-induced neuropathic pain without producing tolerance and may prolong effective opioid analgesia while reducing opioid dependence. In vitro, LY2828360 was a slowly acting but efficacious G protein-biased CB2 agonist, inhibiting cAMP accumulation and activating extracellular signal-regulated kinase 1/2 signaling while failing to recruit arrestin, activate inositol phosphate signaling, or internalize CB2 receptors. In wild-type (WT) mice, LY2828360 (3 mg/kg per day i.p. × 12 days) suppressed chemotherapy-induced neuropathic pain produced by paclitaxel without producing tolerance. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Cannabinoid Receptor | ||
Structure
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