盐酸他克林
| CAS号 | 1684-40-8 | 货号 | BCP29701 |
| 中文名 | 盐酸他克林 | ||
| 英文名 | Tacrine hydrochloride | ||
| 中文别名 | 四氢氨基吖啶; | ||
| 英文别名 | Tacrine HCl;Hydroaminacrine; NSC72108; NSC-72108; NSC72108; | ||
| 分子式 | C13H15ClN2 | 分子量 | 234.73 |
| 生物活性 | Tacrine Hydrochloride is the hydrochloride salt form of tacrine, an aminoacridine derivative with cognitive stimulating property. Although the mechanism of action has not been fully elucidated, tacrine hydrochloride may bind reversibly to cholinesterase, acetylcholinesterase as well as butyrylcholinesterase, thereby decreasing the breakdown of acetylcholine, and prolonging synaptic actions as well as increased release of acetylcholine. In addition, this agent inhibits monoamine oxidase (MAO) and may inhibit the reuptake of catecholamines and serotonin. Finally, a novel mechanism of action studied in animal models suggests tacrine to attenuate the production of interleukin-1beta in the hippocampus and blood, thereby producing central and peripheral anti-inflammatory effects that may play a role in Alzheimer's disease. | ||
| 信号通路 | Neuro Signaling Pathway | ||
| 靶 点 | AChE | ||
结构式
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