SB-297006
CAS No. | 58816-69-6 | Cat. No. | BCP29726 |
Name | SB-297006 | ||
Synonyms | SB 297006;SB297006; | ||
Formula | C18H18N2O5 | M. Wt | 342.35 |
Description | SB-297006 is a potent and selective CCR3 antagonist (IC50 = 39 nM). Displays 250-fold selectivity for CCR3 over other chemokine receptors, including CXCR1, CXCR2, CCR1 and CCR7 (IC50 >27 μM). Inhibits calcium mobilization induced by MCP-4, eotaxin-2 and eotaxin in RBL-2H3 cells transfected with CCR3 (IC50 values are 80, 90 and 210 nM respectively). | ||
Pathways | GPCR/G Protein | ||
Targets | CCR |
Structure
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