SB-297006

  • Chemical Properties
CAS No. 58816-69-6 Cat. No. BCP29726
Name SB-297006
Synonyms SB 297006;SB297006;
Formula C18H18N2O5 M. Wt 342.35
  • Biological Activity
Description SB-297006 is a potent and selective CCR3 antagonist (IC50 = 39 nM). Displays 250-fold selectivity for CCR3 over other chemokine receptors, including CXCR1, CXCR2, CCR1 and CCR7 (IC50 >27 μM). Inhibits calcium mobilization induced by MCP-4, eotaxin-2 and eotaxin in RBL-2H3 cells transfected with CCR3 (IC50 values are 80, 90 and 210 nM respectively).
Pathways GPCR/G Protein 
Targets CCR 

Structure

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