甲磺酸莫非赛定

  • 化学数据
CAS号 Mmethanesulfonate 货号 BCP29839
中文名 甲磺酸莫非赛定
英文名 Morphothiadin methanesulfonate
中文别名
英文别名 GLS4 methanesulfonate; GLS-4 methanesulfonate; GLS 4 methanesulfonate;
分子式 C22H26BrFN4O6S2 分子量 605.49
  • 用途
生物活性 Morphothiadin, also known GLS4, is a potent and selective inhibitor of hepatitis B virus. GLS4 demonstrated potent inhibitory activities in HBV HepG2.2.15 cell assay with an EC50 value of 1nM, and it also exhibited high potency against various drug-resistant HBV viral strains with EC50 values in the range of 10-20nM, more potent than the typical HBV polymerase inhibitors such as lamivudine, telbivudine, and entecavir. Pharmacokinetic profiles of GLS4 were favorable and safety evaluation including acute toxicity and repeated toxicity study indicated that GLS4 was safe enough to support clinical experiments in human.
上下游产品 1092970-12-1(莫非赛定)
信号通路 Microbiology/Virology 
靶 点 HBV 

结构式

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