ZK756326 dihydrochloride
| CAS No. | 1780259-94-0 | Cat. No. | BCP29859 |
| Name | ZK756326 dihydrochloride | ||
| Synonyms | ZK 756326 2HCl;ZK-756326 2HCl;ZK756326 2HCl;ZK 756326 dihydrochloride;ZK-756326 dihydrochloride; | ||
| Formula | C21H30Cl2N2O3 | M. Wt | 429.38 |
| Description | ZK756326 dihydrochloride is a selective, non-peptide CCR8 chemokine receptor agonist (IC50 values are 1.8 and 2.6 μM for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion. | ||
| Pathways | GPCR/G Protein | ||
| Targets | CCR | ||
Structure
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