NT-157
| CAS No. | 1384426-12-3 | Cat. No. | BCP29982 |
| Name | NT-157 | ||
| Synonyms | NT 157; NT157;Tyrphostin NT157;Tyrphostin NT-157; | ||
| Formula | C16H14BrNO5S | M. Wt | 412.26 |
| Description | NT157 is a selective inhibitor of IRS-1/2. NT157 significantly affected the cells' migratory ability. NT-157 induced cytostatic effects, as evidenced by G2/M cell cycle arrest, and did not affect apoptosis. NT157 has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell survival. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Insulin Receptor IGF1R | ||
Structure
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