Cinaciguat hydrochloride
  • 化学数据
CAS号 646995-35-9 货号 BCP30226
中文名 Cinaciguat hydrochloride
英文名 Cinaciguat hydrochloride
中文别名
英文别名 Cinaciguat HCl;BAY 58-2667 hydrochloride;BAY 582667; BAY-582667; BAY582667; BAY 58-2667; BAY-58-2667; BAY58-2667;
分子式 C36H40ClNO5 分子量 602.17
  • 用途
生物活性 Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.Cinaciguat, also known as BAY582667 or BAY58-2667, is a soluble guanylate cyclase activator. Cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus. Cinaciguat exert no direct effects on contractility and relaxation of cardiac myocytes from normal rats. Cinaciguat prevents neointima formation after arterial injury by decreasing vascular smooth muscle cell migration and proliferation.
信号通路 GPCR/G Protein 
靶 点 Guanylate Cyclase 

结构式

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