人源杀菌肽LL 37
| CAS号 | 154947-66-7 | 货号 | BCP30243 |
| 中文名 | 人源杀菌肽LL 37 | ||
| 英文名 | Cathelicidin LL 37 (human) | ||
| 中文别名 | 抗菌肽LL-37; | ||
| 英文别名 | CAP-18;antibacterial peptide LL-37;Cathelicidin LL-37; LL 37; Peptide LL 37 (human gene FALL39 antibacterial); | ||
| 分子式 | C205H340N60O53 | 分子量 | 4493.34 |
| 生物活性 | LL-37 is a synthetic form of a human antimicrobial peptide (37 amino acids), belonging to the cathelicidin family, with antimicrobial, anti-inflammatory, immunostimulating and potential antineoplastic activities. Upon intratumoral injection of the ropocamptide, this peptide increases p53 expression, and induces phosphatidylserine externalization, DNA fragmentation, cell cycle arrest and caspase-independent apoptosis-inducing factor (AIF)/ endonuclease G (EndoG)-mediated apoptotic cell death in susceptible cancer cells. This suppresses tumor cell proliferation. LL-37, a protein secreted by bone marrow cells, circulating leukocytes, and various epithelial tissues, plays a crucial role in the innate host immune defense via the regulation of leukocyte chemotaxis and cytokine production; it also promotes wound healing. | ||
| 信号通路 | Microbiology/Virology | ||
| 靶 点 | Antibiotic | ||
结构式
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