HS1371
| CAS No. | 2158197-70-5 | Cat. No. | BCP30268 |
| Name | HS1371 | ||
| Synonyms | HS-1371；HS 1371; | ||
| Formula | C24H24N4O | M. Wt | 384.48 |
| Description | HS-1371 is a novel kinase inhibitor of RIP3-mediated necroptosis. HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, providing a mechanism of action. Moreover, the compound inhibited TNF-induced necroptosis but did not inhibit TNF-induced apoptosis, indicating that this novel inhibitor has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity. HS-1371 could serve as a potential preventive or therapeutic agent for diseases involving RIP3 hyperactivation. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | RIP | ||
Structure
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