C25-140
| CAS No. | 1358099-18-9 | Cat. No. | BCP30323 |
| Name | C25-140 | ||
| Synonyms | C25140; C25 140；TRAF6-Ubc13 inhibitor C25-140; | ||
| Formula | C26H31N7O | M. Wt | 457.58 |
| Description | C25-140 is a specific, first-in-class small molecule inhibitor of the TRAF6-Ubc13 interaction, binds TRAF6, inhibits TRAF6-Ubc13 interaction and TRAF6 activity; C25-140 effectively reduced TRAF6-mediated ubiquitin chain formation in vitro, impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells; does not effect other E3 ligases (MDM2, TRIM63, ITCH, E6AP and RNF4), also does inhibit E1/E2 reactions. | ||
| Pathways | Protease/Metabolic Enzyme Apoptosis Pathway | ||
| Targets | E1 E2 E3 Enzyme TNF Receptor | ||
Structure
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