NB-360 HCl
| CAS号 | 1262855-97-9 | 货号 | BCP30332 |
| 中文名 | NB-360 HCl | ||
| 英文名 | NB-360 HCl | ||
| 中文别名 | |||
| 英文别名 | NB 360 HCl；NB360 HCl；NB-360 Hydrochloride; | ||
| 分子式 | C21H20ClF4N5O2 | 分子量 | 485.87 |
| 生物活性 | NB-360 is a potent and brain penetrable BACE-1 inhibitor. NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice, a model for amyloid pathology. NB-360 stopped accumulation of activated inflammatory cells in the brains of APP transgenic mice. Upon chronic treatment of APP transgenic mice, patches of grey hairs appeared. | ||
| 信号通路 | Neuro Signaling Pathway | ||
| 靶 点 | Beta secretase | ||
结构式
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