Glaucocalyxin A

CAS No.	79498-31-0	Cat. No.	BCP30380
Name	Glaucocalyxin A
Synonyms	LeukaMenin F; Wangzaozin B; Leucamenin F;
Formula	C20H28O4	M. Wt	332.43

Description	Glaucocalyxin A, which is extracted from the herbs of Rabdosia rubescens, inhibited Akt phosphorylation, suppressed proliferation, and promoted apoptosis in a dose-dependent manner, but not in normal glial cells. Glaucocalyxin A activated caspase-3, decreased BAD phosphorylation, and reduced the expression of X-linked inhibitor of apoptosis protein. Glaucocalyxin A inhibited collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GPⅥ pathway.
Pathways	Protease/Metabolic Enzyme
Targets	Caspase

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